Document Details

Document Type : Article In Journal 
Document Title :
Histopathological Study of Three Leishmania Major Strains
دراسة هستوباثولوجية لثلاث سلالات من الليشمانيا الكبيرة
 
Subject : Original Articles 
Document Language : English 
Abstract : Amastigotes count in inoculated foot pad and histopathological sttjdy of infected mice were performed to study three Leishmania major strains: the Senegafrse strain )4HOM)SNIOO/DKI(SN), the Sudanese strain MHOMJSD/891UG8(SD), and the Saudi strain Mt-IOMJSA/84/JISH(SA). Eight-week-old male BALB/c mice were divided into three groups. Each group was infected with one of the studidd strains. Amastigotes in the inoculated foot of infected mice in the three groups were counted at 30 and 45 days using modified fluorescence diacetate/ethidium bromide viability test. The number of amastigotes in the SA group was found to be significantly lower than that of the other two groups at both durations. There was no significant difference between the number of amastigotes in the SN and SD strains at 30 days. but it was significantly higher in the SN group than that of the SI) group at 45 days post-inoculation. In the animals studied, tissue samples were obtaijied from the skin, liver, spleen, and testes for gross pathological changes mid histopathological evaluation. The SD strain started earlier and led a morn aggressive course. The SN and SA strains were less aggressive. The SA strain showed changes at an earlier time and resulted in a more aggressive course of the disease. The SN and SA strains were less aggressive. The SA strain showed the most chronic course of the three. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 7 
Issue Number : 1 
Publishing Year : 1419 AH
1999 AD 
Number Of Pages : 8 
Article Type : Article 
Added Date : Sunday, October 11, 2009 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عدنان أمينADNAN M. AMINResearcher  
محروسة خضرMAHROUSA A. KHEDRResearcher  

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