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Document Details
Document Type
:
Article In Journal
Document Title
:
Study of Genotoxic Effect of Lorazepam(ativan) on Drosophila melanogaster
دراسة السمية الوراثية لعقار اللورزبام (الأتيفان) بإستخدام حشرة الدروسوفيلا ميلانوجاستر
Subject
:
Biological Sciences
Document Language
:
English
Abstract
:
The mutagenic potentialities of psychoactive drug, lorazepam was tested in Drosophila melanogaster using two test systems, the sex-linked recessive lethals test (SLRL) and the estimation of the activities of the enzymes cholinesterase (CHE) and aliesterase (AliE). Org K, male flies of Drosophila melanogaster were reared on a medium containing two concentrations of the drug, 5 and 10 mg/100 ml medium, and screened for sex-linked recessive lethals. The results indicated that significant number of recessive lethals were induced in Drosophila in all stages of spermatogenesis except in spermatozoa stage at the two doses of the drug, indicating that lorazepam(ativan) is capable of inducing sex-linked recessive lethal mutations in Drosophila melanogaster. Meanwhile, the drug showed a mutagenic effect on the genetic background of each of CHE and AliE, which proves the mutagenic potentiality of the drug.
ISSN
:
1012-1319
Journal Name
:
Science Journal
Volume
:
16
Issue Number
:
1
Publishing Year
:
1424 AH
2004 AD
Number Of Pages
:
11
Article Type
:
Article
Added Date
:
Sunday, October 11, 2009
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ندى حسن التواتي
NADA H.AL-TWATY
Researcher
Files
File Name
Type
Description
22501.pdf
pdf
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