Document Details

Document Type : Article In Journal 
Document Title :
In Vitro Antitrichomonal Effect of Nigella Sativa Aqueous Extract and Wheat Germ Agglutinin
تأثير المستخلص المائى لبذور الحبة السوداء والقمح الجرثومي الملزن على الطفيل المسبب لداء الدويبات الشعرية
 
Document Language : English 
Abstract : Trichomoniasis is one of the most common parasitic sexually transmitted diseases in the world. Metronidazole was known as the most effective drug for human trichomoniasis., however, drug resistance and toxicity appeared. This study was designed to investigate the in vitro inhibitory activity of wheat germ agglutinin and Nigella sativa aqueous extract on the growth and motility of Trichomonas vaginalis in comparison to metronidazole. The inhibitory effect was dose related. Minimal lethal concentration of wheat germ agglutinin was 250µg 250µg/ml in all incubation periods. Minimal lethal concentration of metronidazole was 50µg 50µg/ml after 24 hours. However, lower doses of metronidazole showed a minimal lethal concentration of 25µg 25µg/ml after 48 h and 12µg 12µg/ml after 72 h of incubation; whereas, lower doses of wheat germ agglutinin failed to completely inhibit the parasite growth. Although N. sativa aqueous extract had the lowest effect on parasite growth, producing a lethal effect only after 48 h, it still has a remarkable effect. All drugs remarkably inhibited the motility of the trophozoites. The results showed a promising effect of using wheat germ agglutinin and N. sativa aqueous extract in treating T. vaginalis infection. 
ISSN : 1319-1004 
Journal Name : Medical Science Journal 
Volume : 16 
Issue Number : 2 
Publishing Year : 1430 AH
2009 AD 
Article Type : Article 
Added Date : Saturday, February 27, 2010 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالقادر محمد داود تنكلTonkal, Abdulkader M. D.ResearcherDoctorateatonkal@kau.edu.sa

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